Cheap flights from Medellín to San Francisco (MDE to SFO) from $762

Book at the right time: For international flights, aim to book 6–10 weeks ahead. Last-minute fares on Medellín to San Francisco are rarely cheap, and prices spike sharply within 2 weeks of departure.

Shift your dates by a day or two: Mid-week departures (Tuesday–Wednesday) are almost always cheaper than weekend flights. Even shifting by one day can make a meaningful difference.

Weigh up connecting flights: Connecting flights on Medellín to San Francisco can be 20–40% cheaper than direct options. If you have time to spare, it's worth comparing.

Factor in baggage fees: Low-cost carriers on this route often advertise attractive base fares but charge separately for checked luggage. Always compare the all-in price — a $20 cheaper fare plus $50 baggage fee is no saving. Air Canada and Copa Airlines may have different inclusions, so check each airline's fare conditions.

Search in private browsing: Some booking sites use cookies to track repeat searches and may show higher prices after multiple lookups. Use an incognito or private window — or just use Booked AI, which pulls live prices without any tracking markup.

Compare two one-ways against a return: On some international routes, booking a one-way with one airline and the return with another can undercut a standard return ticket — especially if a budget carrier covers one direction. Check both options with the flexible dates calendar above.

The cheapest flights from Medellín to San Francisco start from $762, with typical prices ranging from $762 to $1,062.

The typical flight time from Medellín to San Francisco is approximately 16 hours and 16 minutes.

Airlines operating this route include Air Canada, Copa Airlines, Avianca, American Airlines, Aeromexico, LATAM Airlines.